Harry V. Vinters, M.D., F.C.A.P.,F.R.C.P.(C), F.F.Path.(R.C.P.I.)
Distinguished Professor of Pathology and Laboratory Medicine (Emeritus)
About
David Geffen School of Medicine at UCLA
Chief, Section of Neuropathology (Emeritus), UCLA Medical Center
Daljit S. & Elaine Sarkaria Chair in Diagnostic Medicine
Member, Brain Research Institute & Mental Retardation Research Center, David Geffen School of Medicine at UCLA
UCLA Path & Lab Med
BOX 951732, 18-170B NPI
Los Angeles, CA 90095-1732
Phone:(310) 825-6191
Email: hvinters@mednet.ucla.edu
Biography
Dr. Harry V. Vinters graduated from the University of Toronto Medical School and trained in Neurology and Neuropathology at the University of Western Ontario Hospitals in London, Canada (1977-81), and Pediatric Neuropathology in Vancouver with Dr. Margaret Norman (1981). He subsequently completed a research fellowship, focusing on the neurobiology of the blood-brain barrier and cerebral microvascular disease, with Dr. Pasquale A. Cancilla at UCLA, where he has been on the faculty since 1985. He currently holds the Daljit S. & Elaine Sarkaria Chair in Diagnostic Medicine, and is Distinguished Professor of Pathology and Laboratory Medicine of Neurology (Emeritus), and has been Chief of the Section of Neuropathology at UCLA Medical Center since 1993.
Dr. Vinters has published over 350 articles, reviews and book chapters on various aspects of neuropathology, ranging from its clinical aspects to issues of molecular pathogenesis. He has also co-authored or edited five books, including a widely used textbook of neuropathology. In addition to his clinical and teaching activities, he has active research programs in several areas, including vascular dementias and the vascular component of Alzheimer disease (especially mediated through amyloid/congophilic angiopathy), neuropathologic substrates of pediatric epilepsy, stroke and cerebrovascular disease. He was the recipient (in 2002) of the Research Award of the Alzheimer’s Association of Los Angeles, Riverside and San Bernardino Counties. He served as Editor-in-Chief of 'Brain Pathology', a leading international journal of clinical and experimental neuropathology, from 2000-2006. In 2004-2005, he served as President of the American Association of Neuropathologists. He currently serves on several editorial boards of major scientific journals.
Specialty
Neuropathology
Affiliations
Semel Institute for Neuroscience and Human Behavior
Education and Degrees
Intern, Internal Medicine, Univ. of Alberta Hospital, Edmonton, Alberta, Canada, 1976-1977.
Resident in Neuropathology, Univ. of Western Ontario Hospitals, London, Ontario, Canada, 1977-1981.
Resident in Pediatric Neuropathology, Vancouver Gen. Hospital and Univ. of British Columbia, Vancouver, B.C, Canada, (Jul-Aug) 1981.
Research Fellow in Pathology (Neuropathology), Univ. of Iowa Hospitals and Clinics, Iowa City, IA, (Jan-Aug) 1982.
Research Fellow in Pathology (Neuropathology), Univ. of California, Los Angeles, CA, 1982-1983.
Assistant Professor of Pathology, Univ. Hospital and Univ. of Western Ontario, London, Ontario, Canada. Attending Neuropathologist, University Hospital, 1984-1985.
Assistant Professor of Clinical Neurological Sciences, Univ. Hospital and Univ. Western Ontario, London, Ontario, Canada, 1984-1985.
Assistant Professor of Pathology and Member, Brain Research Institute, UCLA, Los Angeles, CA 90095; Active Staff, UCLA Medical Center, 1985-1989.
Associate Professor of Pathology and Laboratory Medicine and Member, Brain Research Institute, UCLA, 1989-1993.
Professor of Pathology and Lab Medicine, David Geffen School of Medicine at UCLA & Chief, Section of Neuropathology, UCLA Medical Center; Member, Brain Research Institute, 1993-Present.
Visiting/Rotary Professor of Neurology (Alzheimer Studies) Leiden University Medical Center, Leiden, The Netherlands (total of 9 months: 6 in 1997, 3 in 2004)
Professor of Neurology, David Geffen School of Medicine at UCLA, 2000-Present.
Daljit S. & Elaine Sarkaria Chair in Diagnostic Medicine (endowed chair), 2005-Present.
Awards and Honors
1980 -- Desmond Magner Award, Canadian Tumor Reference Center, National Cancer Institute of Canada
1981 -- R. Samuel McLaughlin Foundation Fellowship
1982-1984 -- Ontario Heart Foundation Stroke Research Fellowship
1983 -- Co-winner, Honorable mention, Weil Award in Experimental Neuropathology, American Association of Neuropathologists
1984-1985 -- Canadian Heart Foundation Scholarship
1988-1989 -- John Douglas French Foundation/Wilson Foundation Fellowship
2001-2006 -- Editor-in-Chief, ‘Brain Pathology’ (Official journal of the Internat’l Society of Neuropathology)
2002 -- Research Award, Alzheimer’s Association of Los Angeles
2004-2005 -- President, American Association of Neuropathologists
Publications
(selected peer-reviewed publications)
Z. Wang, D. Wu, H.V. Vinters. 2002. Hypoxia and reoxygenation of brain microvascular smooth muscle cells in vitro: cellular responses and expression of cerebral amyloid angiopathy-associated proteins. APMIS 110:423-434.
M. Fiala, Q.N. Liu, J. Sayre, V. Pop, V. Brahmandam, M.C. Graves, H.V. Vinters. 2002. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. European J. Clin. Investigation 32:360-371.
J. Goldstine, D.B. Seligson, P. Beizai, H. Miyata, H.V. Vinters. 2002. Tissue microarrays in the study of non-neoplastic disease of the nervous system. J. Neuropathol. Exp. Neurol. 61:653-662.
I.D. Auerbach, S.H. Sung, Z. Wang, H.V. Vinters. 2003. Smooth muscle cells and the pathogenesis of cerebral microvascular disease ("angiomyopathies"). Exper. Molecular Pathol. 74: 148-159.
C. Fu, D.J. Chute, E.S. Farag, J. Garakian, J.L. Cummings, H.V. Vinters. 2004. Comorbidity in dementia. An autopsy study. Arch. Pathol. Lab Medicine 128: 32-38.
H.V. Vinters, I.A. Klement, S.H. Sung, E.S. Farag. 2004. Pathologic issues and new methodologies in the evaluation of non-Alzheimer dementias. Clin. Neuroscience Research 3: 413-426.
C. Zarow, H.V. Vinters, W.G. Ellis, M.W. Weiner, D. Mungas, L. White, H.C. Chui. 2005. Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia. Ann. Neurol. 57: 896-903.
G.A. Marshall, L.A. Fairbanks, S. Tekin, H.V. Vinters, J.L. Cummings. 2006. Neuropathologic correlates of activities of daily living in Alzheimer disease. Alzheimer Dis Assoc Disorders 20: 56-59.
H.V. Vinters. 2006. Neuropathology of amnestic mild cognitive impairment. Arch Neurol 63: 645-646. [commentary/editorial]
Auerbach ID, Vinters HV. 2006. Effects of anoxia and hypoxia on amyloid precursor protein processing in cerebral microvascular smooth muscle cells. J. Neuropatholology Exp. Neurology 65: 610-620.
S.L. Karsten, T-K. Sang, L.T. Gehman, S. Chatterjee, J. Liu, G.M. Lawless, S. Sengupta, R.W. Berry, J. Pomakian, H.S. Oh, C. Schulz, K-S. Hui, M. Wiedau-Pazos, H.V. Vinters, L.I. Binder, D.H. Geschwind, G.R. Jackson. 2006. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron 51: 549-560.
G.W. Small, V. Kepe, L.M. Ercoli, P. Siddarth, S.Y. Bookheimer, K.J. Miller, H. Lavretsky, A.C. Burggren, G.M. Cole, H.V. Vinters, P.M. Thompson, S.-C. Huang, N. Satyamurthy, M.E. Phelps, J.R. Barrio. 2006. PET of brain amyloid and tau in mild cognitive impairment. New England J. of Medicine 355: 2652-2663.
O.A. Selnes, H.V. Vinters. 2006. Vascular cognitive impairment. Nature Clinical Practice Neurology 2: 538-547.
H.C. Chui, C. Zarow, W.J. Mack, W.G. Ellis, L. Zheng, W.J. Jagust, D. Mungas, B.R. Reed, J.H. Kramer, C.C. DeCarli, M.W. Weiner, H.V. Vinters. 2006. Cognitive impact of subcortical vascular and Alzheimer’s disease pathology. Annals of Neurology 60: 677-687.
B.R. Reed, D.M. Mungas, J.H. Kramer, W. Ellis, H.V. Vinters, C. Zarow, W.J. Jagust, H.C.Chui. 2007. Profiles of neuropsychological impairment in autopsy-defined Alzheimer’s disease and cerebrovasculor disease. Brain 130 (Pt. 3): 731-739.
S. Magaki, R. Raghavan, C. Mueller, K.C. Oberg, H.V. Vinters, W.M. Kirsch. 2007. Iron, copper, and iron regulatory protein 2 in Alzheimer’s disease and related dementias. Neuro-sci Letters 418: 72-76.
N. Zelcer, N. Khanlou, R. Clare, Q. Jiang, . E.G. Reed-Geaghan, G.E. Landreth, H.V.Vinters, P. Tontonoz. 2007. Attenuation of neuroinflammation and Alzheimer’s disease pathology by liver x receptors. Proc Natl Acad Sci USA 104: 10601-10606.
H.V. Vinters. 2007. Imaging cerebral microvascular amyloid. Annals Neurol. 62: 209-212. [editorial/ commentary]
J.A. Fein, S. Sokolow, C.A. Miller, H.V. Vinters, F. Yang, G.M. Cole, K.H. Gylys. 2008. Co-localization of amyloid beta and tau pathology in Alzheimer’s disease synaptosomes. American J. Pathol. 172: 1683-1692.
W.J. Jagust, L. Zheng, D.J. Harvey, W.J. Mack, H.V. Vinters, M.W. Weiner, W.G. Ellis, C. Zarow, D. Mungas, B.R. Reed, J.H. Kramer, N. Schuff, C. DeCarli, H.C. Chui. 2008. Neuropathological basis of magnetic resonance images in aging and dementia. Annals of Neurology 63: 72-80. DOI: 10.1002/ana.21296
S.W.Y. Tsang, H.V. Vinters, J.L. Cummings, P.T.-H. Wong, C.P.L.-H. Chen, M.K.P. Lai. 2008. Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer’s disease. Neurobiol. of Aging 29: 1524-1532. DOI 10.1016/j.neurobiolaging.2007.03.014
K.A. Chalmers, G.K. Wilcock, H.V. Vinters, E.K. Perry, R. Perry, C.G. Ballard, S. Love. 2009. Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer’s disease. J. Neurology [in press]. DOI 10.1007/ s00415-009-5000-2
S Ghostine, R. Raghavan, N. Khanlou, H.V. Vinters, K.A. Tong, W.D. Johnson, U. Oyoyo, D. Kido. 2009. Cerebral amyloid angiopathy: micro-hemorrhages demonstrated by magnetic resonance susceptibility-weighted imaging. Neuropathology & Appl. Neurobiology 35: 116-119. DOI: 10.1111/j.1365-2990.2008. 00976.x