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Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease

Purpose

Physical exercise has proven to improve memory including in the elderly. Drugs developed to stop the underlying disease processes that cause Alzheimer's disease may not improve memory on their own without efforts to stimulate brain function. One purpose of the study is to test the clinical benefits of curcumin, a safe and effective compound isolated from the turmeric root (a component of Indian curry spices), which has been found to inhibit several potential disease pathways in Alzheimer's disease. Another purpose of this study is to determine how the addition of a physical exercise program in individuals with early memory problems may affect memory function or brain imaging and blood-based markers associated with Alzheimer's disease. To learn more, please call Mychica at (310) 478-3711 Ext. 42171 or send an email to: This email address is being protected from spambots. You need JavaScript enabled to view it..

Sponsor: VA Office of Research and Development
ClinicalTrials.gov Identifier: NCT01811381

Condition: Intervention: Phase:
Mild Cognitive Impairment Drug: Curcumin
Behavioral: aerobic yoga
Behavioral: non aerobic yoga
Dietary Supplement: Placebo
Phase II

Study Type: Interventional
Study Design: Allocation: A Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Factorial Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Curcumin and Yoga Exercise Effects in Veterans at Risk for Alzheimer's Disease
Time Frames: 0, 3, 6, 9 12 months
Eligibility
Ages Eligible for Study: 50 Years to 90 Years
Genders Eligible for Study: Both
Criteria

Inclusion Criteria:

age between 50 and 90 years;
subjective cognitive complaints;
Mini-Mental Status Exam (MMSE) scores 24;
amnestic cognitive deficits (performance 1.5 standard deviation (SD) below normative means on The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) word list learning test);
essentially intact activities of daily living (FAQ scores < 6);
Sedentary (exercise < 30 minutes a day, 3 times a week);
ambulatory, able exercise safely without cardiovascular symptoms, and able to pass a graded treadmill test modified for the elderly;
able to arrange transportation to the study;
Willing and intellectually able to understand and to sign an informed consent and to adhere to protocol requirements;
community dwelling; and
fluent in written and spoken English
must screen positive for a Modified abbreviated MCI screen on phone, before coming in to clinic for extensive testing.

Exclusion Criteria:

diagnosis of dementia,
concurrent substance abuse disorder,
psychosis or mood disorder,
neurological disease affecting motor or cognitive abilities (e.g. Parkinson's disease),or other significant uncontrolled medical problems,
cannot get up and down from floor,
initiation of any new medications/treatment for cognitive impairment (i.e. cholinesterase inhibitor, memantine) < 6 months prior to study enrollment.

Contact: Mychica at (310) 478-3711 Ext. 42171 or send an email to: This email address is being protected from spambots. You need JavaScript enabled to view it. to participate in this study or for more information.