Drug Discovery and Translational Laboratory
The laboratory is focused on discovery and development of drug candidates for neurodegenerative diseases primarily for Alzheimer’s disease. The laboratory is setup to be multifunctional and equipped for chemistry and biology. Activities include most aspects of preclinical drug discovery, from development of phenotypic screens and target validation, to medicinal chemistry for hit-to-lead optimization, in vitro ADMET studies for lead advancement, in vivo pharmacokinetic (PK) / pharmacodynamic (PD) testing for target engagement, and lead confirmation. The laboratory is part of the UCLA Alzheimer's Drug Development Network (ADDN), a multi-site network leveraging key UCLA capabilities and outside resources to develop novel therapeutics for AD, at the Mary S. Easton Center for Alzheimer's disease Research at UCLA. For more information, please visit the Drug Discovery Laboratory website.