Drug Discovery and Translational Laboratory

The laboratory is focused on discovery and development of drug candidates for neurodegenerative diseases primarily for Alzheimer’s disease. The laboratory is setup to be multifunctional and equipped for chemistry and biology. Activities include most aspects of preclinical drug discovery, from development of phenotypic screens and target validation, to medicinal chemistry for hit-to-lead optimization, in vitro ADMET studies for lead advancement, in vivo pharmacokinetic (PK) / pharmacodynamic (PD) testing for target engagement, and lead confirmation. The laboratory is part of the UCLA Alzheimer's Drug Development Network (ADDN), a multi-site network leveraging key UCLA capabilities and outside resources to develop novel therapeutics for AD, at the Mary S. Easton Center for Alzheimer's disease Research at UCLA. For more information, please visit the Drug Discovery Laboratory website.

John, Varghese, Ph.D.

Alzheimer's Disease Research Center at UCLA, Los Angeles, California
PI, Drug Discovery & Translational Laboratory, Department of Neurology, UCLA
Member, Alzheimer's Disease Program, Mary S. Easton Center for Alzheimer's Disease Research
Member, UCLA's Jonsson Comprehensive Cancer Center (JCCC)
Specialty: Medicinal Chemistry, Drug Discovery, Preclinical Development, Alzheimer's Disease.
Tel: (310) 206-4345
Fax: (310) 794-3148
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Alam, Mohammad Parvez, Ph.D.

Alzheimer's Disease Research Center at UCLA, Los Angeles, California
Postdoctoral Scholar & Fellow, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA
Tel: (310) 825-9239
Fax: (310) 825-6956
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Campagna, Jesus J., M.S.

Alzheimer's Disease Research Center at UCLA, Los Angeles, California
Staff Research Associate, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA
Tel: (310) 825-2133
Fax: (310) 825-6956
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Jagodzinska, Barbara, Ph.D.

Alzheimer's Disease Research Center at UCLA, Los Angeles, California
Senior Medicinal Chemist, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA
Specialty: Medicinal Chemistry, Drug Discovery, Analoging by searching and pharmacophore building based on SAR, Alzheimer's disease.
Tel: (310) 206-4708
Fax: (310) 825-6956
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Spilman, Patricia R., M.A.

Alzheimer's Disease Research Center at UCLA, Los Angeles, California
Senior Staff Scientist, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA
Tel: (310) 794-4787
Fax: (310) 825-6956
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