Alam, Mohammad Parvez, Ph.D.
  • Postdoctoral Scholar & Fellow, Drug Discovery Laboratory, Department of Neurology, David Geffen School of Medicine at UCLA

Alam, Mohammad Parvez, Ph.D.

Contact

Drug Discovery Laboratory
UCLA Department of Neurology
710 Westwood Plaza, Reed Building - Room 3138
Los Angeles, CA 90095-1769
Tel: (310) 825-9239
Fax: (310) 825-6956
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Specialty

Medicinal Chemistry, Drug Discovery, Small Molecule Therapeutics, Fluorescent Bioprobes, Flow Chemistry.


Research Interests

  • Organic Synthesis, Medicinal Chemistry, Computational Modeling and Chemical Biology.
  • Pharmacokinetic evaluation of small molecules to design optimal therapeutic drugs.
  • Flow chemistry utilization for drug discovery

Biography

Dr. Alam has over 6 years of expertise that lies primarily in the area of synthetic organic chemistry. During his Ph.D. under Professor Sidney M. Hecht at the Center for BioEnergetics in the Biodesign Institute at Arizona State University, he synthesized and performed PK analysis of a number of multifunctional radical quenchers (MRQ's). These MRQ’s have potential utility in treating neurodegenerative and mitochondrial disorders. He has synthesized a lead compound on a multi-gram scale for efficacy studies in animal models. Earlier in his graduate studies, he employed solid phase peptide synthesis (SPPS) to make novel DeglycoBleomycins (antitumor, antibiotics). Dr. Alam has also synthesized fluorescent DNA probes to study Bleomycin-DNA interaction and DNA-Protein interaction.

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Current Research

Dr. Alam’s current research focuses on the use of flow chemistry for the development of therapeutics for Alzheimer's disease (AD), other neurodegenerative disorders, and rheumatoid arthritis.

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Education

2007-2009 Master of Science in Chemistry, Indian Institute of Technology Delhi (IITD), INDIA.
2009-2014 Doctor of Philosophy in Chemistry, Arizona State University, Tempe, Arizona.
2014-2015 Postdoctoral Research Associate, Arizona State University, Tempe, Arizona.
2015-Present Postdoctoral Scholar and Fellow, Drug Discovery Lab, UCLA Neurology.

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Publications

  • P Talukder, S Chen, B Roy, P Yakovchuk, MM Spiering, MP Alam, MM Madathil, C Bhattacharya, SJ Benkovic and SM Hecht. Cyanotryptophans as novel fluorescent probes for studying protein conformational changes and DNA–Protein interaction. (submitted)
  • SM Hecht, OM Khdour, MP Alam, S Dey, and Y Chen. Multifunctional radical quenchers exhibiting metabolic stability and bioavailability. (patent in press)
  • MP Alam, B Jagodzinska, J Campagna, P Spilman, V John. C-O bond formation in a microfluidic reactor: high yield SNAr substitution of heteroaryl chlorides. Tetrahedron Letter 2016;57(19):2059-2062. doi:10.1016/j.tetlet.2016.03.095
  • B Roy, C Tang, MP Alam, and SM Hecht. DNA methylation reduces binding and cleavage by bleomycin. Biochemistry 2014;53:6103.
  • C Tang, A Paul, MP Alam, B Roy, WD Wilson, and SM Hecht. A short DNA sequence confers strong bleomycin binding to hairpin DNAs. J Am Chem Soc 2014;136:13715.
  • MP Alam, OM Khdour, PM Arce, Y Chen, B Roy, S Dey, WG Johnson, and SM Hecht. Cytoprotective pyridinol antioxidants as potential therapeutic agents for neurodegenerative and mitochondrial diseases. Bioorg Med Chem 2014;22:4935.
  • S Kendrick, H Kang, MP Alam, MM Madathil, P Agrawal, V Gokhale, D Yang, SM Hecht, and LH Hurley. The dynamic character of the BCL2 promoter i-Motif provides a mechanism for modulation of gene expression by compounds that bind selectively to the alternative DNA hairpin structure. J Am Chem Soc 2014;136:4161.
  • M Agarwal, MP Alam, and C Chakravarty. Thermodynamic, diffusional, and structural anomalies in rigid-body water models. J Phys Chem B 2011;115:6935.

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