Medicinal Chemistry, Drug Discovery, Small Molecule Therapeutics, Fluorescent Bioprobes, Flow Chemistry.
Dr. Alam has over 6 years of expertise that lies primarily in the area of synthetic organic chemistry. During his Ph.D. under Professor Sidney M. Hecht at the Center for BioEnergetics in the Biodesign Institute at Arizona State University, he synthesized and performed PK analysis of a number of multifunctional radical quenchers (MRQ's). These MRQ’s have potential utility in treating neurodegenerative and mitochondrial disorders. He has synthesized a lead compound on a multi-gram scale for efficacy studies in animal models. Earlier in his graduate studies, he employed solid phase peptide synthesis (SPPS) to make novel DeglycoBleomycins (antitumor, antibiotics). Dr. Alam has also synthesized fluorescent DNA probes to study Bleomycin-DNA interaction and DNA-Protein interaction.
Dr. Alam’s current research focuses on the use of flow chemistry for the development of therapeutics for Alzheimer's disease (AD), other neurodegenerative disorders, and rheumatoid arthritis.