Vossel, Keith, M.D., M.Sc.
  • Center Director, Mary S. Easton Center for Alzheimer's Disease Research at UCLA

  • Professor, Department of Neurology, David Geffen School of Medicine at UCLA

Vossel, Keith, M.D., M.Sc.

Contact

Mary S. Easton Center for Alzheimer's Disease Research at UCLA
710 Westwood Plaza, Room C-224
Los Angeles, CA 90095-1769
Tel: (310) 794-3665
Clinic Appts: (310) 794-1195 {Memory Evaluation}
Clinic Fax: (310) 794-7491
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Specialty

Behavioral Neurology, Alzheimer's Disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Early-onset Dementia, Epilepsy

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Education

B.S., Engineering Science and Mechanics, University of Tennessee, Knoxville, TN
M.Sc., Biomedical Engineering, University of Tennessee, Memphis, TN, and University of Memphis, TN
M.D., University of Tennessee College of Medicine, Memphis, TN (Highest Honors)
Internship, Medicine, Harvard Brigham and Women's Hospital, Boston, MA
Residency and Chief Resident, Neurology, Harvard Massachusetts General Hospital and Brigham and Women's Hospital
Fellowship, Behavioral Neurology, University of California, San Francisco, Memory and Aging Center
Fellowship, Neurodegenerative Disease, J. David Gladstone Institutes, San Francisco, CA

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Honors and Awards

2018 Wallin Neuroscience Discovery Fund Award
2013 Outstanding Faculty Mentorship Award Nominee, UCSF Postdoctoral Scholars Association
2011 Paul B. Beeson Career Development Award in Aging Research (K23), NIH/NIA, American Federation for Aging Research, and John A. Hartford Foundation
2011 Distinguished Research Scholar Award, John Douglas French Alzheimer’s Foundation
2010 Alzheimer’s Association Award for Excellence in Research on Alzheimer’s Disease and Related Disorders
2009 Achievement Award in Behavioral Neurology, UCSF Memory and Aging Center
2009 Peter McBean Fellowship in Alzheimer's Research, Gladstone/UCSF
2009 Pilot Research Award in Basic and Clinical/Translational Sciences, UCSF Resource Allocation Program and NIH/NIA
2006 Partners in Excellence Award, Partners Healthcare
2003 Alpha Omega Alpha Distinguished Graduate Award, UT, Memphis College of Medicine
2003 Medical Student Prize for Excellence in Neurology, American Academy of Neurology
2002 Alpha Omega Alpha, National Medical Honor Society, UT, Memphis College of Medicine
2002 Joseph Collins Foundation Scholarship, UT, Memphis College of Medicine
2001 Gooch Scholarship for Academic Achievement, UT, Memphis College of Medicine

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Board Certifications

American Board of Neurology and Psychiatry

Professional Organizations

Member, Society of Neuroscience
Fellow, American Neurological Association
Member, American Academy of Neurology

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Publications

    • Johnson, EL, Krauss GL, Kucharska-Newton A, Albert MS, Brandt J, Walker KA, Yasar S, Knopman DS, Vossel K, Gottesman RF. Dementia in late-onset epilepsy: the Atherosclerosis Risk in Communities study. Neurology 2020. In Press.
    • Peters ST, Fahrenkopf A, Choquette JM, Vermilyea S, Lee MK, Vossel K. Ablating tau reduces hyperexcitability and moderates electroencephalographic slowing in transgenic mice expressing A53T human α-synuclein. Frontiers in Neurology 2020, 11:563. doi: 10.3389/fneur.2020.00563. PMCID: PMC7316964
    • Borghesani V, Hinkley LB, Ranasinghe KG, Thompson MMC, Shwe W, Mizuiri D, Lauricella M, Europa E, Honma S, Miller Z, Miller B, Vossel K, Houde JF, Gorno- Tempini ML, Nagarajan SS. Taking the sub-lexical route: brain dynamics of reading in the semantic variant of Primary Progressive Aphasia. Brain. In Press.
    • Ranasinghe KG, Cha J, Hinkley LB, Beagle AJ, Jagust W, Miller BL, Rankin KP, Rabinovici GD, Vossel KA (co-senior author), Nagarajan SS (co-senior author). Neurophysiological signatures in Alzheimer’s disease are distinctly associated with tau, amyloid-beta accumulation, and cognitive decline. Science Translational Medicine 2020. doi: 10.1126/scitranslmed.aaz4069. PMCID: In Process
    • Gamache J, Kemper L, Steuer E, Leinonen K, Choquette J, Hlynialuk C, Benzow K, Vossel KA, Xia W, Koob M, Ashe KH. Developmental pathogenicity of 4-repeat human tau is lost with the P301L mutation in genetically 1 matched tau-transgenic mice. Journal of Neuroscience 2019, 40:220-236. doi: 10.1523/JNEUROSCI.1256- 19.2019. PMCID: PMC6939485
    • Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS. Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer’s disease. Scientific Reports 2019, 9:5686. doi: 10.1038/s41598-019-41794-x. PMCID: PMC6450891
    • La AL, Walsh CM, Neylan TC, Vossel KA, Yaffe K, Krystal AD, Miller BL, Karageorgiou E. Long-term trazodone use and cognition: a potential therapeutic role for slow-wave sleep enhancers. Journal of Alzheimer’s Disease 2019, 67:911-921. doi: 10.3233/JAD-181145. PMCID: PMC6398835
    • Zeman A, Byruck M, Tallis P, Vossel K, Tranel D. Touching the void - first and third person perspectives in two cases of autobiographical amnesia linked to epilepsy. Neuropsychologia 2018, 110:55-64. doi: 10.1016/j.neuropsychologia.2017.07.007.
    • Lutsey PL, Chen N, Lakshminarayan K, Gottesman RF, Mosley TH, Knopman DS, Vossel KA, Mirabelli MC, Alonso A. Impaired lung function, lung disease and risk of incident dementia. American Journal of Respiratory and Critical Care Medicine 2018 Nov 15. doi: 10.1164/rccm.201807-1220OC. PMCID: PMC6543713
    • Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. The Lancet Neurology 2017, 16:311-322. doi: 10.1016/S1474-4422(17)30044-3. PMCID: PMC5973551
    • Beagle AJ, Darwish SM, Ranasinghe KG, La AL, Karageorgiou E, Vossel KA. Relative incidence of seizures and myoclonus in Alzheimer’s disease, dementia with Lewy bodies, and frontotemporal dementia. Journal of Alzheimer’s Disease 2017, 60:211-223. doi: 10.3233/JAD-170031. PMCID: PMC5608587
    • Karageorgiou E and Vossel KA. Brain rhythm attractor breakdown in Alzheimer’s disease: functional and pathological implications. Alzheimer's & Dementia 2017, 13:1054-1067. doi: 10.1016/j.jalz.2017.02.003. PMCID: PMC5585024
    • Perry DC, Brown J, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee S, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Li AN, Vargas JN, Hwang J, Ossenkoppele R, Brown AB, Huang EJ, DeArmond SJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain 2017, 140:3329-3345. doi: 10.1093/brain/awx254. PMCID: PMC5841140
    • Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS. Distinct patterns of resting state neural synchronizations in primary progressive aphasia variants. Brain 2017, 140:2737- 2751. doi: 10.1093/brain/awx217. PMCID: PMC5841154
    • Miyamoto T, Stein L, Taneja P, Djukic B, Knox J, Vossel K, Mucke L. Phosphorylation of tau at Y18, but not tau-Fyn binding, is required for tau to modulate NMDA receptor- dependent excitotoxicity in primary neuronal culture. Molecular Neurodegeneration 2017, 12:41. doi: 10.1186/s13024-017-0176-x. PMCID: PMC5438564
    • Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Houde JF, Nagarajan SS. Abnormal vocal behavior predicts executive and memory deficits in Alzheimer’s disease. Neurobiology of Aging 2017, 52:71-80. doi: 10.1016/j.neurobiolaging.2016.12.020. PMCID: PMC5359035
    • Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Barnes DE, Mantle M, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease. Annals of Neurology 2016, 80:858-870. doi: 10.1002/ana.24794. PMCID: PMC5177487
    • Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL. Distinct subtypes of behavioral-variant frontotemporal dementia based on patterns of network degeneration. JAMA Neurology 2016, 73:1078-1088. doi: 10.1001/jamaneurol.2016.2016. PMCID: PMC5024785
    • Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Lazaris A, Cantwell A, Vogel J, Baker SL, O’Neil JP, Janabi M, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease. Brain 2016, 139:1551-1567. doi: 10.1093/brain/aww027. PMCID: PMC5006248
    • Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL. Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage. Neurology 2016, 86:600-610. doi: 10.1212/WNL.0000000000002373. PMCID: PMC4762418
    • Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Vossel KA, Mucke L. Neural network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Annals of Clinical and Translational Neurology 2015, 2:1012-1028. doi: 10.1002/acn3.257. PMCID: PMC4693622
    • Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Yu G, Mucke L. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. The Journal of Cell Biology 2015, 209:419-433. doi: 10.1083/jcb.201407065. PMCID: PMC4427789
    • Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Dowling AF, Honma SM, Finucane MM, Scherling C, Miller BL, Nagarajan SS, Vossel KA. Regional functional connectivity predicts distinct cognitive impairments in Alzheimer's disease spectrum. NeuroImage Clinical 2014, 5:385–395.  doi: 10.1016/j.nicl.2014.07.006. PMCID: PMC4145532
    • Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurology 2013, 70:1158-66. doi: 10.1001/jamaneurol.2013.136. PMCID: PMC4013391
    • Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW. ApoE4 and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease. Neurocase 2013, 19:295- 301. doi: 10.1080/13554794.2012.667124. PMCID: PMC3655113
    • Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Yu G, Palop JJ, Mucke L. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences U.S.A. 2012, 109:E2895-2903. doi: 10.1073/pnas.1121081109. PMCID: PMC3479491
    • Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. Tau reduction prevents Aβ-induced defects in axonal transport. Science 2010, 330:198. doi: 10.1126/science.1194653. PMCID: PMC3024010
    • Agosta F (co-first author), Vossel KA (co-first author), Miller BL, Migliaccio R, Bonasera S, Boxer AL, Karydas A, Possin KL, Gorno-Tempini ML. Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia. Proceedings of the National Academy of Sciences U.S.A. 2009, 106:2018-22. doi: 10.1073/pnas.0812697106. PMCID: PMC2644156
    • Vossel KA, Miller BL. New approaches to treatment of frontotemporal lobar degeneration. Current Opinion in Neurology 2008, 21:708–716. doi: 10.1097/WCO.0b013e328318444d. PMCID: PMC2744321

Books

    • Cho TA, Vossel KA, Yu TW, Greer DM. Neurology. In Pocket Medicine, The Massachusetts General Hospital Handbook of Internal Medicine, 3rd Edition. 2007; 9.1-9.11.

Chapters in Books

    • Nagarajan SS, Ranasinghe KG, Vossel KA. Brain Imaging With Magnetoencephalography During Rest and During Speech and Language Processing. In Genomics, Circuits and Pathways for the Clinical Neuroscientist. 2016; 233-245.

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