Chang, Timothy S., M.D., Ph.D.
  • Assistant Professor of Neurology, Movement Disorders Program, David Geffen School of Medicine at UCLA

Specialty

Neurology, Alzheimer's Disease, and Movement Disorders.

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Biography

Timothy Chang received his bachelor's degree from Stanford University, and M.D. and Ph.D from the University of Wisconsin, Madison. He completed residency in Neurology and fellowship training in Neurobehavior and Movement Disorders at UCLA. During his fellowship training, Dr. Chang completed a postdoctoral research fellowship in genetics before being appointed Assistant Professor of Neurology at UCLA.

His clinical expertise focuses on Alzheimer’s disease and related dementias, particularly those with associated movement disorders. These include Progressive Supranuclear Palsy, Corticobasal Syndrome, Lewy Body Dementia, Frontotemporal Dementia, and Parkinson's disease.

Dr. Chang's research laboratory uses computational approaches on large datasets to understand the genetic and clinical factors that may lead to and affect the course of Alzheimer’s disease and related dementias. The long term goal is to seek new therapies that can be individualized for each person.

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Education

2003-2007 B.S. Biomedical Computation, Stanford University, Stanford, CA
2007-2014 M.D., School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI
2009-2012 Ph.D., Clinical Investigation. Institute for Clinical and Translational Research, Department of Biostatistics, University of Wisconsin-Madison, Madison, WI
2014-2015 Internship in Medicine, St. Mary's Medical Center, Long Beach, CA
2015-2018 Residency in Neurology, University of California Los Angeles, Los Angeles, CA
2018-2020 Fellowship in Neurology Movement Disorders, University of California Los Angeles, Los Angeles, CA

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Honors and Awards

2014 American Academy of Neurology Medical Student Prize for Excellence in Neurology
2007 Stanford Class Award of Excellence
2007 Entrepreneurship Week Innovation Challenge National Creativity Winner
2007 Best Paper Award (for “Haptic Guidance”), IEEE World Haptics 2007
2020 Abstract Award, 2020 Turken Research Award and Symposium

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Board Certifications

California Medical License (active)
Board Certified by American Board of Psychiatry and Neurology (active)

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Publications

Full list of publications: https://www.ncbi.nlm.nih.gov/myncbi/1Je75kwd1uwQc/bibliography/public/

    • Gendron JM, Haque A, Gendron N, Chang T, Asami T, Wang ZY. Chemical Genetic Dissection of Brassinosteroid-Ethylene Interaction. Molecular Plant.2008 Mar;1(2):368-79. doi: 10.1093/mp/ssn005. PMID: 19825546; PMCID: PMC2975526.
    • International Warfarin Pharmacogenetics Consortium, Klein TE, … Chang T, et. al. Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med. 2009 Feb 19;360(8):753-64. doi: 10.1056/NEJMoa0809329. PMID: 19228618; PMCID: PMC2722908.
    • Chang TS, Coen MH, La Rue A, Jonaitis E, Koscik RL, Hermann B, and Sager MA. Machine Learning Amplifies the Effect of Parental Family History of Alzheimer’s Disease on List Learning Strategy. J Int Neuropsychol Soc.2012 May;18(3):428-39. doi: 10.1017/S1355617711001834. Epub 2012 Feb 10. PMID: 22321601; PMCID: PMC3348337.
    • Chang T. Personalizing Medicine: Beyond Race. Virtual Mentor. American Medical Association Journal of Ethics.2012 Aug 1;14(8):628-34. doi: 10.1001/virtualmentor.2012.14.8.jdsc1-1208.  PMID: 23351318.
    • Chang TS. Towards Translational Biomedical Informatics: Interpretable Models for Etiology, Early Diagnosis, and Prognosis [dissertation]. [Madison (WI)]: University of Wisconsin-Madison; 2012.
    • Chang TS, Lemanske RF, Guilbert TW, Gern JE, Coen MH, Evans MD, Gangnon RE, Page CD, Jackson DJ. Evaluation of the Modified Asthma Predictive Index in High-Risk Preschool Children. J Allergy Clin Immunol Pract. 2013 Mar;1(2):152-6. doi: 10.1016/j.jaip.2012.10.008. PMID: 24187656; PMCID: PMC3811153.
    • Tomasallo CD, Hanrahan L, Tandias A, Chang TS, Cowan K, Guilbert TW. Estimating Wisconsin Asthma Prevalence Using Clinical Electronic Health Records and Public Health Data. Am J Public Health. 2014 Jan;104(1):e65-73. doi: 10.2105/AJPH.2013.301396. Epub 2013 Nov 14. PMID: 24228643; PMCID: PMC3895403.
    • Chang TS, Lemanske RF, Mauger D, Fitzpatrick A, Sorkness CA, Szefler SJ, Gangnon RE, Page CD, Jackson DJ. Childhood Asthma Clusters and Response to Therapy in Clinical Trials. J Allergy Clin Immunol.2014 Feb;133(2):363-9. doi: 10.1016/j.jaci.2013.09.002. Epub 2013 Oct 15. PMID: 24139497; PMCID: PMC3960405.
    • Chang TS, Jensen MB. Haemodilution for acute ischaemic stroke.Cochrane Database Syst Rev. 2014 Aug 27;(8):CD000103. doi: 10.1002/14651858.CD000103.pub2. Review. PMID: 25159027; PMCID: PMC4181849.
    • Chang TS, Gangnon RE, David Page C, Buckingham WR, Tandias A, Cowan KJ, Tomasallo CD, Arndt BG, Hanrahan LP, Guilbert TW. Sparse modeling of spatial environmental variables associated with asthma. J Biomed Inform. 2015 Feb;53:320-9. doi: 10.1016/j.jbi.2014.12.005. Epub 2014 Dec 20. PMID: 25533437; PMCID: PMC4355087.
    • Chang TS, Teng E, Elashoff D, Grill JD. Optimizing Effect Sizes With Imaging Enrichment and Outcome Choices for Mild Alzheimer Disease Clinical Trials. Alzheimer Dis Assoc Disord. 2017 Jan-Mar;31(1):19-26. doi: 10.1097/WAD.0000000000000150. PMID: 27196535; PMCID: PMC5116001.
    • Chang TS, Patel CB, Keener AM, Keselman I, Jamal NI. Movements Here Today, Gone Tomorrow: Images in Clinical Neurology Case of Hyperglycemic Hemichorea. Neurohospitalist. 2017 Jul;7(3):150. doi: 10.1177/1941874416671648. Epub 2016 Oct 3. PMID: 28634509; PMCID: PMC5467814.
    • Chang TS, Buchipudi A, Fonarow GC, Pfeffer MA, Singer JS, Cheng EM. Physicians Voluntarily Using an EHR-Based CDS Tool Improved Patients' Guideline-Related Statin Prescription Rates: A Retrospective Cohort Study. Appl Clin Inform. 2019 May;10(3):421-445. doi: 10.1055/s-0039-1692186. Epub 2019 Jun 19. PMID: 31216590; PMCID: PMC6584145.
    • Swarup V*, Chang TS*, Duong DM, Dammer EB, Dai J, Lah JJ, Johnson ECB, Seyfried NT, Levey AI, Geschwind DH. Identification of conserved proteomic networks in neurodegenerative dementia.  Cell Rep. 2020 Jun 23;31(12):107807. doi: 10.1016/j.celrep.2020.107807. PMID: 32579933.
    • Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Rep. 2020 Nov 17;33(7):108398. doi: 10.1016/j.celrep.2020.108398. PMID: 33207193; PMCID: PMC7842189.
    • Chang TS*, Ding Y*, Freund MK*, Johnson R*, Schwarz T*, Yabu JM, Hazlett C, Chiang JN, Wulf DA, UCLA Precision Health Data Discovery Repository Working Group, Geschwind DH, Butte MJ, Pasaniuc B. Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors. iScience. 2021 Mar 19;24(3):102188. doi: 10.1016/j.isci.2021.102188. Epub 2021 Feb 12. PMID: 33615196; PMCID: PMC7879099.

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