Coppola, Giovanni, M.D.
  • Associate Professor in Residence, Departments of Psychiatry and Neurology, David Geffen School of Medicine at UCLA

  • Director, Semel Center for Informatics and Personalized Genomics

  • Co-Director, UCLA Informatics Center for Neurogenetics and Neurogenomics

Coppola, Giovanni, M.D.


#1524 Gonda Neuroscience and Genetics Research Center
University of California Los Angeles
695 Charles E. Young Dr. South
Los Angeles, CA 90095
Tel: (310) 794-4172
Fax: (310) 794-9613
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.



Dementia, Alzheimer's Disease, Frontotemporal Dementia, Genetics, Genomics.

Research Interests

Genetics and Genomics of Neurodegenerative Diseases.


  • School of Medicine, Federico II University, Naples, Italy, 1995.
  • Neurology residency, Department of Neurological Sciences, School of Medicine, Federico II University, Naples, Italy, 2000.

Honors and Awards

2011 John Douglas French Alzheimer's Foundation Distinguished Scholar Award


Publications (selected peer-reviewed publications)

  • Zabel M, Schrag M, Crofton A, Tung S, Beaufond P, Van Ornam J, Dininni A, Vinters HV, Coppola G, Kirsch WM. A shift in microglial beta-amyloid binding in Alzheimer’s disease is associated with cerebral amyloid angiopathy. Brain Pathol 2012 Nov 8. doi: 10.1111/bpa.12005. PMID: 23134465
  • Stein JL, Medland SE, Vasquez AA, …Toga A, …Apostolova LG, …Coppola G, …Thompson PM, …et al (ENIGMA consortium). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics 2012;44:552-561. doi: 10.1038/ng.2250. PMID: 22504417
  • Lee GJ, Lu PH, Medina LD, Rodriguez-Agudelo Y, Melchor S, Coppola G, Braskie MN, Hua X, Apostolova LG, Leow AD, et al. Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations. J Neurol Neurosurg Psychiatry 2013;84(2):154-162. PMID: 23085935
  • Sha SJ, Takada LT, Rankin KP, Yokoyama JS, Rutherford NJ, Fong, JC, Khan B, Karydas A, Baker MC, Dejesus-Hernandez M, et al. Frontotemporal dementia due to C9ORF72 mutations: Clinical and imaging features. Neurology 2012;79:1002–1011. PMID: 22875087; PMCID: PMC3430713
  • Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet 2012;1:3500–3512. PMID: 22556362; PMCID: PMC3392107
  • Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G. Plasma methionine sulfoxide in persons with familial Alzheimer’s disease mutations. Dement Geriatr Cogn Disord 2012;33:219–225. PMID: 22584618
  • Ringman JM, Coppola G, Elashoff D, Rodriguez-Agudelo Y, Medina LD, Gylys, K, Cummings JL, and Cole GM. Cerebrospinal Fluid Biomarkers and Proximity to Diagnosis in Preclinical Familial Alzheimer's Disease. Dement Geriatr Cogn Disord 2012;33:1–5. PMID: 22343824
  • Damoiseaux JS, Seeley WW, Zhou J, Shirer WR, Coppola G, Karydas A, Rosen HJ, Miller BL, Kramer JH, and Greicius MD. Gender Modulates the APOE 4 Effect in Healthy Older Adults: Convergent Evidence from Functional Brain Connectivity and Spinal Fluid Tau Levels. J Neurosci 2012;32:8254-8262. PMID: 22699906; PMCID: PMC3394933
  • Coppola G, and Geschwind DH. Genomic medicine enters the neurology clinic. Neurology 2012;79:112–114. PMID: 22675078
  • Khan B, Yokoyama J, Takada L, Sha S, Rutherford N, Fong J, Karydas A, Wu T, Ketelle R, Maker M, Hernandez-DeJesus M, Coppola G, Geschwind DH, Rademakers R, Lee S, Rosen H, Rabinovici G, Seeley W, Rankin K, Boxer A, Miller BL. Atypical, slowly progressive behavioral variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion. J Neurol Neurosurg Psychiatry 2012;83:358-364. PMID: 22399793; PMCID: PMC3388906
  • DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW, Josephs KA, Coppola G, Geschwind DH, Wszolek ZK, Feldman H, Knopman DS, Petersen RC, Miller BL, Dickson DW, Boylan KB, Graff-Radford NR, Rademakers R. Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS. Neuron 2011;72:245-256.
  • Ringman JM, Taylor K, Teng E, Coppola G, Gylys K. Longitudinal Change in CSF Biomarkers in a Pre-Symptomatic Carrier of an APP Mutation. Neurology 2011;76:2124-2125.
  • Finch N, Carrasquillo MM, Baker M, Rutherford NJ, Coppola G, DeJesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa KJ, Karydas AM, Sengdy P, Gonzalez J, Seeley WW, Johnson N, Beach TG, Mesulam M, Forloni G, Kertesz A, Knopman DS, Uitti R, White CL, Caselli R, Lippa C, Bigio EH, Wszolek ZK, Binetti G, Mackenzie IR, Miller BL, Boeve BF, Geschwind DH, Younkin SG, Dickson DW, Petersen RC, Graff-Radford N, Rademakers R. TMEM106B regulates progranulin expression and protects against disease in GRN mutation carriers. Neurology 2011;76:467-474.
  • Li S, Overman JJ, Katsman D, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST. Molecular control of axonal sprouting after stroke: an age-related sprouting transcriptome in cortical neurons. Nat Neurosci 2010;13:1496-504.
  • Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo E, Geschwind DH, Masliah E, Chiba AA, Tuszynski MH. Neuroprotective Effects of BDNF in Rodent and Primate Models of Alzheimer’s Disease. Nat Med 2009;15(3):331-337.
  • Coppola G, Karydas A, Rademakers R, Wang Q, Baker M, Hutton M, Miller BL, Geschwind, DH. Gene expression study on peripheral blood identifies progranulin mutations. Ann Neurol 2008;64:92-96.


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