Jason Hinman, M.D., Ph.D.
Interim Co-Center Director
About
Interim Co-Center Director, Mary S. Easton Center for Alzheimer's Research and Care at UCLA
Associate Professor in Residence, Department of Neurology, David Geffen School of Medicine at UCLA
Interim Co-Director, Katherine and Benjamin Kagan Alzheimer's Disease Treatment Development Program
Director, Hinman Lab
David Geffen School of Medicine at UCLA
UCLA Neurology Clinic
Clinic Appts: (310) 794-1195 {Memory Evaluation}
Clinic Fax: (310) 794-7491
Biography
I am a physician-scientist and vascular neurologist dedicated to reducing the overall burden of stroke and dementia through excellent clinical care and translational research. My lab is broadly focused on cellular and molecular mechanisms of vascular and glial injury related to stroke and cognitive impairment. We use animal, cellular, and 3D models of vascular brain injury together with gene expression and biomarker tools to identify novel diagnostic and therapeutic pathways for cerebrovascular disease. My graduate work focused on identifying age-related changes in axons and myelin in macaques and rodents. In 2012, I received the NINDS R25 Translational Neuroscience Fellowship and completed training in stroke modeling and neural repair with Dr. S. Thomas Carmichael (UCLA). In 2013, I received an NINDS K08 to study mechanisms of axonal degeneration after subcortical stroke. Notably, my lab has participated in several studies that identify cellular and molecular changes occurring within the peri-infarct niche next to small white matter ischemic lesions in both rodents and humans. We have expanded this work to include translational efforts to identify biomarkers for vascular cognitive impairment. Currently, my lab directs multiple drug discovery experiments using animal models of subcortical stroke as well as directing biomarker development for several large national consortia and networks including MarkVCID, DISCOVERY Network, and the DIVERSE VCID study. I am currently Vice Chair of Research, Co-PI of the UCLA R25 Translational Neuroscience Training Grant, and serve as the educational liaison for the UCLA Vascular Neurology Fellowship Program. Through continued excellence and translational effort, we hope to catalyze new diagnostic tools and therapeutic treatments for patients with cerebrovascular disease and post-stroke cognitive impairment.
Specialty
Neurology, stroke and cerebrovascular disease.
Board Certifications
American Board of Psychiatry and Neurology
Medical Board of California
Affiliations
Alzheimer's Disease Research Center (ADRC)
Katherine and Benjamin Kagan Alzheimer's Disease Treatment Development Program
Education and Degrees
Doctor of Medicine, Boston University School of Medicine
Doctor of Philosophy in Molecular Medicine, Boston University School of Medicine
Awards and Honors
Dorothy Dillon Eweson Lecture Series Award, American Federation for Aging Research (2019)
Fellow-to-Resident Teaching Award, UCLA Neurology (2013)
Jean P. Riehl Award for Research Accomplishments in Residency, UCLA Neurology (2011)
Magna cum laude, Boston University School of Medicine (2007)
Publications
Peer Reviewed
Rost NS, Brodtmann A, Pase MP, van Veluw SJ, Biffi A, Duering M, Hinman JD, Dichgans M. Post-Stroke Cognitive Impairment and Dementia. Circ Res. 2022 Apr 15;130(8):1252-1271. Epub 2022 Apr 14. PMID: 35420911.
Hashimoto T, Kunieda T, Honda T, Scalzo F, Ali L, Hinman JD, Rao NM, Nour M, Bahr-Hosseini M, Saver JL, Raychev R, Liebeskind D. Reduced Leukoaraiosis, Noncardiac Embolic Stroke Etiology, and Shorter Thrombus Length Indicate Good Leptomeningeal Collateral Flow in Embolic Large-Vessel Occlusion. AJNR Am J Neuroradiol. 2022 Jan;43(1):63-69. Epub 2021 Nov 18. PMID: 34794948; PMCID: PMC8757540.
Bahr-Hosseini M, Bikson M, Iacoboni M, Liebeskind DS, Hinman JD, Carmichael ST, Saver JL. PRIMED2 Preclinical Evidence Scoring Tool to Assess Readiness for Translation of Neuroprotection Therapies. Transl Stroke Res. 2022 Apr;13(2):222-227. Epub 2021 Jul 1. PMID: 34196953; PMCID: PMC8918446.
Mun KT, Hinman JD. Inflammation and the Link to Vascular Brain Health: Timing Is Brain. Stroke. 2022 Feb;53(2):427-436. Epub 2022 Jan 10. PMID: 35000422.
Elahi FM, Harvey D, Altendahl M, Brathaban N, Fernandes N, Casaletto KB, Staffaroni AM, Maillard P, Hinman JD, Miller BL, DeCarli C, Kramer JH, Goetzl EJ. Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans. Sci Rep. 2021 Aug 10;11(1):16198. Erratum in: Sci Rep. 2022 Feb 1;12(1):2008. PMID: 34376699; PMCID: PMC8355229.
Pajewski NM, Elahi FM, Tamura MK, Hinman JD, Nasrallah IM, Ix JH, Miller LM, Launer LJ, Wright CB, Supiano MA, Lerner AJ, Sudduth TL, Killeen AA, Cheung AK, Reboussin DM, Wilcock DM, Williamson JD. Plasma amyloid beta, neurofilament light chain, and total tau in the Systolic Blood Pressure Intervention Trial (SPRINT). Alzheimers Dement. 2021 Nov 17. PMID: 34786815.
Hashimoto T, Kunieda T, Honda T, Scalzo F, Sharma LK, Hinman JD, Rao NM, Nour M, Bahr-Hosseini M, Saver JL, Raychev R, Liebeskind DS. Heterogeneity between proximal and distal aspects of occlusive thrombi on pretreatment imaging in acute ischemic stroke. Neuroradiol J. 2021 Oct 5:19714009211049713. PMID: 34609921.
Liebeskind DS, Hinman JD, Kaneko N, Kitajima H, Honda T, De Havenon AH, Feldmann E, Nogueira RG, Prabhakaran S, Romano JG, Callas PW, Schneider DJ. Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease. Front Neurol. 2021 Feb 25;12:646309. PMID: 33716947; PMCID: PMC7947292.
Gonzalez NR, Jiang H, Lyden P, Song S, Schlick K, Dumitrascu O, Quintero-Consuegra MD, Toscano JF, Liebeskind DS, Restrepo L, Rao N, Hinman J, Alexander MJ, Schievink W, Piantadosi S, Saver JL. Encephaloduroarteriosynangiosis (EDAS) revascularization for symptomatic intracranial atherosclerotic stenoocclusive(ERSIAS) Phase-II objective performance criterion trial. Int J Stroke. 2021 Aug;16(6):701-709. Epub 2020 Oct 29. PMID: 33115382.
Kim SJ, Morales JM, Yaghi S, Honda T, Scalzo F, Hinman JD, Raychev R, Sharma LK, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Intracranial atherosclerotic disease mechanistic subtypes drive hypoperfusion patterns. J Neuroimaging. 2021 Jul;31(4):686-690. Epub 2021 Apr 30. PMID: 33930227.
Kakarla V, Kaneko N, Nour M, Khatibi K, Elahi F, Liebeskind DS, Hinman JD. Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2. J Cereb Blood Flow Metab. 2021 Jun;41(6):1179-1192. Epub 2021 Feb 2. PMID: 33530831; PMCID: PMC8142132.
* Featured on journal cover
Yaghi S, Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. J Neuroimaging. 2021 Feb 10. PMID: 33565162.
Hinman JD, Ngo KJ, Kim D, Chen C, Abraham CR, Ghanbari M, Ikram MA, Kushner SA, Kawaguchi R, Coppola G, Goth K, Bellusci S, Hernandez I, Kosik KS, Fogel BL. miR-142-3p Regulates Cortical Oligodendrocyte Gene Coexpression Networks Associated with Tauopathy. Hum Mol Genet. 2021 Feb 8:ddaa252. PMID: 33555315.
Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM; MarkVCID Consortium. MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols. Alzheimers Dement. 2021 Jan 21. Epub ahead of print. PMID: 33480172.
Kaneko N, Satta S, Komuro Y, Muthukrishnan SD, Kakarla V, Guo L, An J, Elahi F, Kornblum HI, Liebeskind DS, Hsiai T, Hinman JD. Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection. Stroke. 2021 Jan;52(1):260-270. Epub 2020 Nov 9. PMID: 33161843; PMCID: PMC7769899.
* Accompanying editorial: https://doi.org/10.1161/STROKEAHA.120.033119
** 1st Prize – 2022 Progress & Innovation Award, Stroke Journal
Raychev R, Saber H, Saver JL, Hinman JD, Brown S, Vinuela F, Duckwiler G, Jahan R, Tateshima S, Szeder V, Nour M, Colby GP, Restrepo L, Kim D, Bahr-Hosseini M, Ali L, Starkman S, Rao N, Nogueira RG, Liebeskind D. Impact of eloquent motor cortex-tissue reperfusion beyond the traditional thrombolysis in cerebral infarction (TICI) scoring after thrombectomy. J Neurointerv Surg. 2020 Dec 18:neurintsurg-2020-016834. Epub ahead of print. PMID: 33443113.
Kaneko N, Ullman H, Ali F, Berg P, Ooi YC, Tateshima S, Colby GP, Komuro Y, Hu P, Khatibi K, Ponce Mejia LL, Szeder V, Nour M, Guo L, Chien A, Vinuela F, Nemoto S, Mashiko T, Sehara Y, Hinman JD, Duckwiler G, Jahan R. In Vitro Modeling of Human Brain Arteriovenous Malformation for Endovascular Simulation and Flow Analysis. World Neurosurg. 2020 Sep;141:e873-e879. Epub 2020 Jun 18. PMID: 32565379.
Hayden EY, Huang J, Nunez S, Lee JT, Welch A, Frautschy S, Cole G, Teng E, Hinman JD. Modeling mixed vascular and Alzheimer’s dementia using focal subcortical ischemic stroke in human ApoE4-TR:5XFAD transgenic mice. Transl Stroke Res. 2020 Feb 21. PMID: 32086779.
Altendahl M, Maillard P, Walter S, Wolf A, Singh B, Kakarla V, Azizkhanian I, Xiao G, Sheth S, Leng M, Elashoff D, Harvey D, Fox E, You M, Cotter D, Kramer JH, DeCarli C, Elahi FM, Hinman JD. An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury. Plos ONE. 2020 Jan 24;15(1):e0227835. PMID: 31978079.
Sozmen EG, DiTullio DJ, Rosenzweig S, Hinman JD, Bridges SP, Marin MA, Kawaguchi R, Coppola G, Carmichael ST. White matter stroke induces a unique oligo-astrocyte niche that inhibits recovery. J. Neurosci. 2019 Nov 20;39(47):9343-9359. PMID: 31591156.
Azizkhanian I, Sheth S, Iavarone AT, Lee S, Kakarla V, Hinman JD. Plasma Lipid Profiling Identifies Biomarkers of Cerebral Microvascular Disease. Front. Neurol. 2019. Aug. 29; 10:950. PMID: 31555203.
Hayden EY, Putman J, Nunez S, Shin WS, Oberoi M, Charreton M, Dutta S, Li Z, Komuro Y, Joy MT, Bitan G, MacKenzie-Graham A, Jiang L, Hinman JD. Ischemic axonal injury up-regulates MARK4 in cortical neurons and primes tau phosphorylation and aggregation. Acta Neuropathol Commun. 2019. Aug 20;7(1):135. PMID: 31429800.
Kaneko N, Minhas A, Tateshima S, Colby GP, Szeder V, Hinman JD, Nour M, Jahan R, Duckwiler G. Pre-procedural simulation for precision stent-assisted coiling of cerebral aneurysm. Interv Neuroradiol. 2019. Aug;25(4):419-422. PMID: 30922200.
Hinman JD. The power of observation in neurology then and now – notes from Charcot’s library. JAMA Neurol. 2019. Jul 29. PMID: 31355684.
Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH. “Liquid biopsy” of white matter hyperintensity in functionally normal elders. Front Aging Neurosci. 2018. Nov 9;10:343. PMID: 30483114.
Barh Hosseini M, Woolf G, Sharma LK, Hinman JD, Rao NM, Yoo B, Jahan R, Starkman S, Nour M, Raychev R, Liebeskind DS, Saver JL. The frequency of substantial salvageable penumbra in thrombectomy-ineligible patients with acute stroke. J Neuroimaging. 2018. Nov;28(6):676-682. PMID: 30010229.
Sheth SA, Verma A, Malhotra K, Tang X, Tateshima S, Jahan R, Hinman JD. Human endothelial cell collection from the middle cerebral artery in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2018. Mar;27(3):669-672. PMID: 29103865.
Coban H, Tung S, Yoo B, Vinters HV, Hinman JD. Molecular disorganization of axons adjacent to human cortical microinfarcts. 2017. E-pub: Front Neurol. Aug 16;8: 405. PMID: 28861035.
Yu S, Ma SJ, Liebeskind DS, Yu D, Li N, Qiao XJ, Shao X, Yan L, Yoo B, Scalzo F, Hinman JD, Sharma LK, Rao N, Jahan R, Tateshima S, Duckwiler GR, Saver JL, Salamon N, Wang DJ. ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients. J Cereb Blood Flow Metab. 2017; Jan. Epub ahead of print. PMID: 282668894.
Lou X, Yu S, Scalzo F, Starkman S, Ali LK, Kim D, Rao NM, Hinman JD, Vespa PM, Jahan R, Tateshima S, Gonzalez NR, Duckwiler GR, Saver JL, Yoo B, Salamon N, Lyu J, Ma L, Wang DJ, Liebeskind DS. Multi-delay ASL can identify leptomeningeal collateral perfusion in endovascular therapy of ischemic stroke. Oncotarget 2017;Jan 10; 8(2):2437-2443. PMID: 27974692.
Sozmen EG, Rosenzweig S, Llorente IL, DiTullio DJ, Machnicki M, Vinters HV, Havton LA, Giger RJ, Hinman JD, Carmichael ST. Nogo receptor blockade overcomes remyelination failure after white matter stroke and stimulates functional recovery in aged mice. PNAS 2016;Dec 27; 113(52):E8453-E8462. PMID: 27956620.
Lui D, Scalzo F, Rao NM, Hinman JD, Kim D, Ali LK, Saver JL, Sun W, Dai Q, Lui X, Liebeskind DS. Fluid-Attenuated Inversion Recovery Vascular Hyperintensity Topographyt, Novel Imaging Marker for Revascularization in Middle Cerebral Artery Occlusion. Stroke 2016;Nov; 47(11):2763-2769.
Brumm AJ, Nunez S, Doroudchi MM, Kawaguchi R, Duan J, Pellegrini M, Lam L, Carmichael ST, Deb A, Hinman JD. Astrocytes Can Adopt Endothelial Cell Fates in a p53-dependent Manner. Mol Neurobiol 2016 Aug;54(6):4584-4596. PMID: 27389775.
Nunez S, Doroudchi MM, Gleichman AJ, Ng KL, Llorente IL, Sozmen EG, Carmichael ST, Hinman JD. 2016. A versatile murine model of subcortical white matter stroke for the study of axonal degeneration and white matter neurobiology. J Vis Exp. 109. PMID: 27023377.
Lui D, Scalzo F, Starkman S, Rao NM, Hinman JD, Kim D, Ali LK, Saver JL, Noorian AR, Ng K, Liang C, Sheth SA, Yoo B, Liu X, Liebeskind DS. 2015. DWI lesion patterns predict outcome in stroke patients with thrombolysis. Cerebrovasc Dis. 40(5-6):279-85. PMID: 26513397.
Hinman JD, Lee MD, Tung S, Vinters HV, Carmichael ST. 2015. Molecular disorganization of axons adjacent to human lacunar infarcts. Brain. 138(Pt 3):736-45. PMID: 25614025.
Hinman JD, Rao NM, Yallapragada A, Capri J, Souda P, Whitelegge J, Yong WH, Jahan R, Quinones-Baldrich W, Saver JL. 2013. Drip, ship, grip and then slice and dice: Comprehensive stroke center management of cervical and intracranial emboli. Front Neurol. 4(104). PMID: 23908644.
Hinman JD, Rasband MN, Carmichael ST. 2013. Remodeling of the axon initial segment after focal cortical and white matter stroke. Stroke. 44(1):182-9. PMID: 23233385.
* Featured on journal cover
Chen CD, Sloane JA, Li H, Aytan N, Giannaris EL, Zeldich E, Hinman JD, Dedeoglu A, Rosene DL, Bansal R, Luebke J, Kuro-o M, Abraham CR. 2013. The anti-aging protein klotho enhances oligodendrocyte maturation and myelination of the central nervous system. J. Neurosci. 33(5):1927-39. PMID: 23365232.
Hinman JD, Lerner JT, Salamon N. 2012. MRI appearance of Enterobacter cloacae brain abscesses in a preterm neonate. J Pediatric Neurorad. 1(2).
Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR. 2008. Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia. 56(1):118-33.
Hinman JD, Peters A, Cabral H, Rosene DL, Hollander W, Rasband MN, Abraham CR. 2006. Age-related molecular reorganization at the node of Ranvier. J. Comp. Neurol. 495(4): 351-62.
Chen CD, Oh SY, Hinman JD, Abraham CR. 2006. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J. Neurochem. 97(1): 30-43.
Oh SY, Ellenstein A, Chen C, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR. 2005. The amyloid precursor protein interacts with notch receptors. J. Neurosci. Res. 82(1): 32-42.
Hinman JD, Duce JA, Siman RA, Hollander W, Abraham CR. 2004. Activation of calpain-1 in myelin and microglia in the white matter of the aged rhesus monkey. J. Neurochem. 89(2): 430-441.
Sloane JA, Hinman JD, Lubonia M, Hollander W, Abraham CR. 2003. Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey. J. Neurochem. 84(1): 157-68.
Mourton T, Hellberg CB, Burden-Gulley SM, Hinman J, Rhee A, Brady-Kalnay SM. 2001. The PTPμ protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts. J. Biol. Chem. 276 (18): 14896-14901.