Tirth Patel, M.D., Ph.D.

Research MD Fellow, Jason Hinman Lab 
David Geffen School of Medicine at UCLA

UCLA Memory Clinic
Clinic Appts: (310) 794-1195 {Memory Evaluation}
Clinic Fax: (310) 794-7491

Biography

Tirth’s interest in neurology stems from his time as an undergraduate student at UCLA when he participated in the Student Stroke Team, where he had the unique opportunity to get involved in the care of acute stroke patients and learn from UCLA’s top stroke neurologists. After graduating, he took this passion for neurology with him to Washington University in St. Louis. There, he joined the MD/PhD program, obtaining his PhD in the laboratory of Dr. David Holtzman. His research there focused on the role of tau protein in the pathogenesis and therapeutics of Alzheimer’s disease and other neurodegenerative diseases. He returned to UCLA for his neurology residency. He will be joining the Easton Center as a neurobehavior fellow starting July 2024 while performing postdoctoral research in the laboratory of Dr. Jason Hinman. His research will focus on the molecular mechanisms of lymphovascular dysfunction in tauopathy.

Specialty

Alzheimer's disease, dementia, and memory disorders.

Board Certifications

Board eligible

Affiliations

Physicians

Education and Degrees

B.Sc., Microbiology, Immunology, Molecular Genetics, and minor in Biomedical Research, University of California, Los Angeles

MD, PhD, Combined Degree Program in Neuroscience, Medical Scientist Training Program (MSTP), Washington University in St. Louis, School of Medicine

Residency, Internal Medicine, University of California, Los Angeles

Residency, Neurology, UCLA Medical Center

Publications

Sheehan PW, Nadarajah CJ, Kanan MF,…,Patel TK,…,Musiek ES. 2023. An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology. Neuron 111(15), 2383-2398.e7. https://doi.org/10.1016/j.neuron.2023.05.006

Patel TK, Geha R, Patel A, Benhammou J, Manesh R, Patel S. 2023. A real dilemma. Journal of Hospital Medicine, 18(8), 748-752.

Olson JM, Evans CJ, Mondal BC,…,Patel T,…,Clark IE, Banerjee U. 2019. Expression-based cell lineage analysis in Drosophila through a course-based research experience for early undergraduates. G3 9(11):3791-3800. PMID: 31690598; PMCID: PMC6829132

Patel TK, Habimana-Griffin L, Gao X, Xu B, Achilefu S, Alitalo K, McKee CA, Sheehan PW, Musiek ES, Xiong C, Coble D, Holtzman DM. 2019. Dural lymphatics regulate clearance of extracellular tau from the CNS. Mol Neurodegener 14:11. PMID: 30813965; PMCID: PMC6391770

Patel TK, Holtzman DM. 2018. Dual therapy for Aβ amyloidosis in AD: A successful one-two combo. J Exp Med, 215(5):1267-1268. PMCID: PMC5940274

Yanamandra K*, Patel TK*, Jiang H, Schindler S, Ulrich JD, Boxer AL, Miller BL, Kerwin DR, Gallardo G, Stewart F, Finn MB, Cairns NJ, Verghese PB, Fogelman I, West T, Braunstein J, Robinson G, Keyser J, Roh J, Tirth K Patel, Knapik SS, Hu Y, Holtzman DM. 2017 Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy. Sci Transl Med, 9(386):pii: eaal2029. PMCID: PMC5727571 [Co-first author]

Holth J, Patel T, Holtzman DM. 2017 Sleep in Alzheimer's Disease - Beyond Amyloid. Neurobiol Sleep Circadian Rhythms, 2:4-14. PMCID: PMC5312809

Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM. 2016 Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy. Ann Clin Transl Neurol, 3(6):434-442. PMCID: PMC4891997

Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM. 2015 Analysis of in vivo turnover of tau in a mouse model of tauopathy. Mol Neurodegener, 10:55. PMCID: PMC4621881

Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM. 2014 Neuronal activity regulates extracellular tau in vivo. J Exp Med, 211(3):387-93. PMCID: PMC3949564