Associate Professor in Residence, Neuroscience IDP

Member, Brain Research Institute

Director, Zhefeng Guo Laboratory

Zhefeng Guo Laboratory
4155 Reed Building
Los Angeles, CA 90095
Lab: (310) 794-9503
Tel: (310) 206-8773


Zhefeng Guo is a structural biologist and biochemist who joined the UCLA School of Medicine faculty in 2008. Dr. Guo earned his B.S. in Microbiology (1995) at Shandong University and M.S. in Biochemistry (1998) at Peking University in China. Then Dr. Guo came to the United States for graduate studies and received his Ph.D. in Biochemistry (2003) at UCLA, where he was focused on developing electron paramagnetic resonance (EPR) methods to study protein structure, dynamics, and folding in Wayne Hubbell's laboratory. In 2004, Dr. Guo joined David Eisenberg's research group for postdoc training, working on the structural characterization of amyloid fibrils using the approaches of protein engineering and X-ray crystallography. His laboratory is currently investigating the structure and fibrillization mechanism of amyloid fibrils related to a wide range of human disorders such as Alzheimer's, Parkinson's, and prion diseases, with the goal of developing molecular diagnostics and therapeutics for amyloid diseases.


Microbiology and Biochemistry.


COMPLETED - Pilot Project 14.2: Structural Characterization of γ-Secretase with EPR Spectroscopy

Zhefeng Guo Laboratory